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Credelio Quattro Flavored Chewable Tablet for Dogs & Puppies Description
Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) is the broadest* parasite protection of its kind covering 6 types of parasites in one chewable tablet. It protects against ticks, fleas, heartworm disease and the three intestinal worms that can be passed to humans — tapeworms, roundworms and hookworms†.
Credelio Quattro is effective and works fast where it counts. It kills over 99% of fleas within 8 hours of administration and remains effective for an entire month. What's more, Credelio Quattro contains lotilaner that kills ticks** twice as fast†† as sarolaner in Simparica Trio and afoxolaner in NexGard†††.
This FDA-approved medication delivers all the protection your dog needs in a convenient monthly chewable. It uses four powerful ingredients to provide the broadest* protection that lasts all month long by covering 6 types of parasites. Credelio Quattro comes in a tasty, easy-to-give chewable that's also meat allergy friendly***. In fact, Credelio Quattro was accepted by nearly 9 out of 10 dogs.
*Based on label comparison of the number of parasite types covered in a chewable that covers ticks
**Amblyomma americanum (lone star tick)
***Elanco Animal Health. Data on file.
†Uncinaria stenocephala
††Based on the time to statistical significance vs. control in a study on Day 21 and Day 28 for reinfestations. The study compared Credelio (lotilaner)—not Credelio Quattro, which contains lotilaner as well as moxidectin, praziquantel, and pyrantel—to the active ingredients in Simparica Trio (sarolaner, moxidectin, and pyrantel) and NexGard (afoxolaner).
††† Reif KE, Kollasch TM, Neilson JC, Herrin BH, Ryan WG, Bell MC, Beltz MS, Dryden MW, Jesudoss Chelladurai JRJ, Miller KR, Sutherland CJ. Comparative speed of kill provided by lotilaner (Credelio), sarolaner(Simparica Trio), and afoxolaner (NexGard) to control Amblyomma americanum infestations on dogs. Parasit Vectors. 2024 Jul 20;17(1):313."
Which animals/pets is Credelio Quattro Flavored Chewable Tablet for Dogs & Puppies for?
Dogs and Puppies (8 weeks of age or older)
Credelio Quattro Flavored Chewable Tablet for Dogs & Puppies uses
Credelio Quattro: The broadest* parasite protection of its kind covering 6 types of parasites in one chewable tablet *Based on label comparison of the number of parasite types covered in a chewable that covers ticks; Brings Peace of Mind: This monthly flea and tick treatment also protects against heartworm disease and three intestinal worms that can be passed to humans – roundworms, hookworms† and tapeworms †Uncinaria stenocephala; Easy-to-Give Chewable: This FDA-approved parasite protection comes in a flavored chewable tablet that is given once a month with food; Prescription Only: Credelio Quattro is a prescription medication for puppies and dogs at least 8 weeks old and weighing at least 3.3 lbs.; Crafted for sensitive dogs, Credelio Quattro comes in a delicious beef-flavored chewable that's meat-allergen free.
What does Credelio Quattro Flavored Chewable Tablet for Dogs & Puppies do?
Credelio Quattro contains four active pharmaceutical ingredients, lotilaner, moxidectin, praziquantel, and pyrantel (as pamoate salt).
Lotilaner is an ectoparasiticide belonging to the isoxazoline group. Lotilaner inhibits insect and acarine gamma-aminobutyric acid (GABA)-gated chloride channels. This inhibition blocks the transfer of chloride ions across cell membranes, which results in uncontrolled neuromuscular activity leading to death of insects and acarines. The selective toxicity of lotilaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines' GABA receptors versus mammalian GABA receptors.
Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
Praziquantel's mode of action is not precisely known, but treated tapeworms undergo muscular paralysis accompanied by a rapid influx of calcium ions and the disruption of the tegument.
Pyrantel is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, causing paralysis and death or expulsion of the parasite.
Credelio Quattro Flavored Chewable Tablet for Dogs & Puppies side effects
Possible side effects may include : diarrhea, vomiting, lethargy, anorexia, dermatitis, weight loss, itching or alopecia.
Credelio Quattro Flavored Chewable Tablet for Dogs & Puppies ingredients
Lotilaner, Moxidectin, Praziquantel, and Pyrantel
Credelio Quattro Flavored Chewable Tablet for Dogs & Puppies overdose: What to do?
Contact your nearest emergency animal hospital
What to know before using Credelio Quattro Flavored Chewable Tablet for Dogs & Puppies
Not for use in humans. Keep this and all drugs out of reach of children. Wash hands after handling. If accidentally ingested, seek medical attention immediately. Keep Credelio Quattro in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose. Lotilane one of the ingredients in Credelio Quattro is a member of the Isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving Isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Prior to use, dogs should be tested for existing heartworm infections and treated at the discretion of your veterinarian. Administer orally once monthly and with food.
How is Credelio Quattro Flavored Chewable Tablet for Dogs & Puppies sold?
Sold in 1 count / 1 month supply or 6 count / 6 month supply for the following dog sizes : 3.3-6 lbs Yellow, 6.1-12 lbs Pink, 12.1-25 lbs Orange, 25.1-50 lbs Green, 51-100 lbs Blue.
Manufacturer
Elanco
Overview
Use as directed by your Veterinarian.
Dosage and Administration:
Credelio Quattro is given orally once a month, at the minimum dosage of 9mg/lb (20mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5mg/kg) praziquantel and 2.28 mg/lb (5mg/kg) pyrantel )as pamoate salt). Quattro must be administered with food. Care should be taken to ensure that the dog consumes the complete dose. If vomiting occurs within an hour after administration, readminister a new dose. If a dose is missed, give Credelio Quattro immediately and resume a monthly dosing schedule.
Body Weight / Tablets to Administer / Lotilaner per Tab (mg) / Moxidectin per Tab (mg) / Praziquantel per Tab (mg) / Pyrantel per Tab (mg)
3.3-6lbs / 1 / 56.25 / 0.056 / 14.25 / 14.25
6.1-12 / 1 / 112.5 / 0.113 / 28.5 / 28.5
12.1-25 / 1 / 225 / 0.225 / 57 / 57
25.1-50 / 1 / 450 / .45 / 114 / 114
50.1-100 / 1 / 900 / .9 / 228 / 228
> 100 Administer the appropriate combination of tablets
Prior to use, dogs should be tested for existing heartworm infections and treated at the discretion of your veterinarian. Administer orally once monthly and with food.
Main Ingredients
Lotilaner, Moxidectin, Praziquantel, and Pyrantel