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K9 Advantix II for Dogs

(364 reviews)
Veterinary Diet Item
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K9 Advantix II for Dogs

$19.99
One-time purchase
$11.99 AutoShip & Save up to 40%
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Weight:
Month Supply: 1 Month Supply
Weight:
Month Supply: 1 Month Supply
This item requires vet authorizationWe’ll contact your vet clinic for you.
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California Residents: Prop. 65 Warning

This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. For more information, go to www.P65Warnings.ca.gov

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Product Overview

Your dog’s world is full of adventures. Fleas, ticks and mosquitoes shouldn't be part of them. That's why there's K9 Advantix II, a convenient topical that provides 5-way protection against fleas, ticks, mosquitoes, biting flies, and lice in a single monthly dose. It's vet-recommended* flea, tick and mosquito treatment and prevention without a prescription.

This flea topical for dogs begins working the same day, killing fleas within 12 hours of application to help control active infestations. K9 Advantix II also prevents flea infestations by preventing the development of all flea stages: eggs, larvae, pupae and adults. Breaking the flea life cycle means less scratching for your dog and more peace of mind for you. What's more, K9 Advantix II for Dogs works through contact, killing and repelling fleas and ticks so they don't have to bite your dog to die. Even indoor dogs need protection against fleas and ticks––they can be brought inside on people or by other pets. By killing fleas on your dog before they lay eggs, K9 Advantix II helps control fleas and helps prevent re-infestation in your dog’s environment.

The fragrance-free formula becomes waterproof 24 hours after application. It remains effective and won't rub off after shampooing or swimming. Best of all, K9 Advantix II for Dogs is easy to use. Apply one topical dose every 4 weeks for reliable protection against fleas, ticks, mosquitoes, biting flies and lice.

Formulated for dogs and puppies 7 weeks of age and older weighing 4 lbs. or more, K9 Advantix II is available in multiple sizes: Small (4-10 lbs), Medium (11-20 lbs), Large (20-55 lbs), and Extra Large (over 55 lbs). Choose the one that aligns with your dog’s current weight to ensure proper dosing.

DO NOT USE ON CATS.

*Elanco Animal Health. Data on file. REF-24002
Dogs (7 weeks of age or older)
* 5-WAY PROTECTION: For 30 days, 1 dose of K9 Advantix II treats and prevents fleas, ticks, mosquitoes, biting flies, and lice on dogs; DO NOT USE ON CATS.

* SAME-DAY FLEA CONTROL: These tick and flea drops for dogs kills fleas on dogs within 12 hours of application, helping provide relief from active infestations.

* REPELS & KILLS THROUGH CONTACT: K9 Advantix II kills and repels fleas and ticks through contact, so they don't have to bite your dog to die.

* VET-RECOMMENDED*: K9 Advantix II for Dogs is vet-recommended* flea, tick, and mosquito treatment and prevention without a prescription.

* EASY-TO-APPLY MONTHLY PROTECTION: This convenient flea and tick topical is easy to apply, and no prescription is needed.

* WATERPROOF FLEA DROPS: K9 Advantix II for dogs is waterproof after 24 hours of application, so it continues working after bathing, swimming or walks in the rain; it stays on and won't rub off.

This flea topical for dogs stops existing flea infestations by killing adult fleas, and it prevents the development of flea eggs and flea larvae so they can't reinfest your dog.
Between day 6 and 9 after application, certain adverse reactions have occurred in rare cases. These include weakness, depression, and unsteadiness. These signs resolved on their own without intervention by day 10 after application. In laboratory effectiveness studies, certain adverse reactions occurred after application (and were directly attributed to the use of this medication). They could also be secondary to the burden of a pre-existing condition or of intestinal parasites. These signs include diarrhea, bloody stools, vomiting, anorexia, lethargy, coughing, ocular discharge, or nasal discharge. Application site reactions may include stiff or greasy hair, white deposits on the hair, or mild erythema (redness of the skin). These reactions often resolve between 2 and 48 hours with no intervention.
Imidacloprid, Permethrin, Pyriproxyfen
Contact your closest emergency animal hospital.
Dogs should be isolated for a minimum of 12 hours after K9 Advantix II is applied to ensure adequate and thorough dry time if you have cats in the home. K9 Advantix II Adverse Reactions may be referenced if the pet experiences an adverse reaction to this medication.Never handle or allow a child to handle a treated dog until the application site is completely dry. Ensure this lack of contact by treating the dog in the evening hours and by stopping them from sleeping with any human family member.
Sold in 2, 4, 6, and 12 month supplies based on your dog's weight. Boxes are color coded to your dog's weight.
  • Green: Up to 10 pounds
  • Teal: 11 - 20 pounds
  • Red: 21 - 55 pounds
  • Blue: Over 55 pounds
Elanco
Do not handle treated dogs, or allow children to do so, until the site of application dries. You can help ensure this by treating your dog in the evening and not allowing them to sleep with children or other human family members.
Use only on dogs. DO NOT USE ON CATS or other animals. Do not apply to dogs weighing less than 4 lbs.

Remove applicator tube from the package. Use scissors and peel down foil.

Hold applicator tube in an upright position. Pull cap off tube.

Turn cap around and place other end of cap back on tube.

Twist cap to break seal, then remove cap from tube.

The dog should be standing for easy application. Evenly apply entire contents of the tube along the top of the dog's back, from the shoulder down to the base of the tail. The number of spots depends on the size and weight of your dog (please refer to the product label). At each spot, part the hair until skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your dog’s eyes, or allow your dog to ingest this product.
Active Ingredients  /   % By Weight
Imidacloprid                      8.80%
Permethrin*                      44.00%
Pyriproxyfen                      0.44%
Other Ingredients              46.76%
 
Total                                 100.0%
 
*cis/trans ratio: max 55% (±) cis and min 45% (±) tr

About This Product

Customer Reviews

4.9
364 reviews
5 339
4 25
3 0
2 0
1 0
Lisa H Verified Purchase
September 25, 2026

Got it specifically for mosquito protection

We have had other flea and tick formulas, but we got this specifically because it also offers a mosquito repellent.

Nicole D Verified Purchase
August 10, 2026

works very well

Kathy C Verified Purchase
August 6, 2026

Great flea and tick protection

Works well and easy to apply.

Liz Q Verified Purchase
August 4, 2026

No seizures!!

I have done older rescues that are sensitive to most flea and tick treatments. One gets seizures from many of these products . K9 Advantix has never caused a reaction in any if my five dogs. Highly recommend. Works well. No fleas or ticks in any if these guys since using this product.

Richard K Verified Purchase
July 29, 2026

One dose and gone.

My dog had a pretty good batch of fleas. We were pulling five to ten of them off him each day. I gave him one tablet and have yet to see another flea after more than ten days.

Doris S Verified Purchase
April 16, 2026

I've been using this for at least 8years every summer on my sweet bulldog. I've had zero issues with fleas in the house or on my pet.

Kathleen M Verified Purchase
April 14, 2026

I tried other flea and tick solutions and i was still finding ticks on my dogs. I have been using Advantix for over 15 years on my Springer Spaniels and it works.

PATRICIA T Verified Purchase
September 10, 2025

K-9 Advantix ll for dogs

K9 Advantix® brand to kill and repel fleas, ticks and mosquitoes. With one easy-to-apply topical treatment, K9 Advantix® II works all month. Wouldn't use anything else.

Faith R Verified Purchase
April 22, 2023

I love that it not only kills fleas and ticks but eggs and larvae… and mosquitos and lice… great… my sister uses it all the time…

Steven h
November 3, 2022

I love allivet’s pricing and free shipping. I order all my pet medicines from allivet.

Larry R Verified Purchase
October 10, 2022

ME AND MY DOGS JUST LOVE THIS PRODUCT NOT A SINGLE FLEA SINCE WE STARTED USING IT AND PET MEDS MAKES IT SI EASY TO ORDER MORE LOVE IT

Gerarda W Verified Purchase
August 30, 2022

I ordered K9 Advantix II because my vet told me that it is a great product

Glenda M Verified Purchase
June 15, 2022

I have found this works the best for my dogs.

Tina N Verified Purchase
March 31, 2022

No complaints it works as expected.

Patricia A Verified Purchase
March 31, 2022

Works great and LESS expensive that most!

Dee p Verified Purchase
March 31, 2022

Good price, ease of ordering

Karrie S Verified Purchase
March 31, 2022

I've been using this faithfully on my Shi-Poo since she was a puppy. She is now 8 and never has any pest problems. Works for me!

Barbara W Verified Purchase
March 9, 2022

Advantix II works best for my dog. Living in South Florida, my Buddy is exposed to fleas and mosquitoes more that other parts of the country. It works here, it will word anywhere.

Denise O Verified Purchase
March 9, 2022

The best price I could find online. Happy with buying experience.

April G Verified Purchase
January 26, 2022

Never had a problem with Advantix. I feel secure as a multiple dog owner.

C.W. O Verified Purchase
November 15, 2021

I like this flea and tick medicine out of all the stuff on the market.

Gary R Verified Purchase
November 3, 2021

We’ve been using this with the girls for years.

Annette m Verified Purchase
November 3, 2021

Keeps ticks and fleas away!

Anthony B Verified Purchase
October 25, 2021

I have been very happy with this product

Joyce R Verified Purchase
October 6, 2021

best price for mail order; quick delivery; very nice customer service.

Michael M Verified Purchase
September 7, 2021

I compared the protection provided by Advantix II with Frontline, and Advantix II offers much more protection at a lower cost — both of which are important. Even with the 20% off promo Frontline offered, this is by far the better buy. After all, saving money IS one of the main reasons we shop at Allivet.

Michael C Verified Purchase
August 27, 2021

ALWAYS GREAT PRICES AND SERVICE...Thank you!

Joanne T Verified Purchase
August 23, 2021

I love Allivet pharmacy and I order all Cocabean medicine here.

Mary J Verified Purchase
August 23, 2021

Works awesome

Glenna B Verified Purchase
August 23, 2021

Very good

Bonnie H Verified Purchase
August 15, 2021

This product works quite well for my little Zoe. Delivery of the product is fast.

Karrie S Verified Purchase
August 12, 2021

I have used this faithfully on my little 12 lb Shi-poo and she has never had a problem with any bugs. She also gets a Sentinel Spectrum chew every month as well.

Betsy G Verified Purchase
August 2, 2021

This product was recommended so we are trying it out!

Dena B Verified Purchase
July 13, 2021

This is the best price I’ve seen in quite a while. I feel this product is the best for my puppy dogs

Donna P Verified Purchase
July 8, 2021

My baby is a little over 5#. K9 Advantix works the best for him. I want only the best for him and Allivet provides that for me.

Cathy B Verified Purchase
July 8, 2021

I like this product, but lasts more like 3 weeks

Gene K Verified Purchase
June 25, 2021

Helps my pet.

Lisa S Verified Purchase
June 22, 2021

good product, awesome price

Judy a Verified Purchase
June 22, 2021

I have five dogs and this is a good price

Victor N Verified Purchase
June 22, 2021

Lowest price

Beverly H Verified Purchase
June 22, 2021

It works & this is great price !

Kelly J Verified Purchase
June 22, 2021

1/2 off sale! My dogs use this every month!

Linda S Verified Purchase
June 22, 2021

K9Advantix II keeps fleas and ticks off monthly. Works great!

Donna S Verified Purchase
June 22, 2021

Great !

HERSCHEL B Verified Purchase
June 22, 2021

Works well, mainly we use it for Mosquitoes & Ticks for our dog.

Catherine J Verified Purchase
June 22, 2021

Good prices

Doina J Verified Purchase
June 8, 2021

Very satisfied !

Sara H Verified Purchase
June 8, 2021

I always buy thru Allivet- great service, prices and products. My dogs has been on this for 9 years - works as advertised.

Cynthia D Verified Purchase
May 26, 2021

It's just the best

Charles M Verified Purchase
May 25, 2021

The best price I have ever got

Laneen H Verified Purchase
May 25, 2021

We have fleas, ticks & mosquitos in Michigan and this works

Donna M Verified Purchase
May 25, 2021

Did some research and this product was highly recommended by veterinarians. The price was the best on Allivet autoship!

Debra W Verified Purchase
May 25, 2021

It works!

Laneen H Verified Purchase
May 25, 2021

I wish this worked on humans. Once a month on my dogs and it works

David M Verified Purchase
May 25, 2021

Best price available.

Joshua M Verified Purchase
May 3, 2021

nice price

Sherley L Verified Purchase
May 3, 2021

This works and is the best out there.

Barbara S Verified Purchase
May 3, 2021

Best prices

Marsha C Verified Purchase
May 3, 2021

Efficient n cheaper

Dawn K Verified Purchase
May 3, 2021

I use K9 Advantix for all my dogs because it is safe for their health and stops ticks and mosquito bites very well. I once bought another brand from a pet store, and my poor dog started shaking all over. I had to wipe him off with a wet, soapy towel right away to get as much off as possible. This is the only brand I will use.

Christine B Verified Purchase
May 3, 2021

Fast service. Best price.

Carl t Verified Purchase
May 3, 2021

works for me

Carl t Verified Purchase
May 3, 2021

works for me

Wendy M Verified Purchase
May 3, 2021

Help my dog from allergy

Carolyn H Verified Purchase
May 3, 2021

I've been using this product for years with no issues. I hate how it makes the dogs gross and greasy for a few days but it is worth knowing I won't have to worry about ticks for a few weeks.

Anthony R Verified Purchase
April 26, 2021

about 40% less than my vet was charging me for exact same 6 month supply. Although my vet prices for visits and vaccinations are very reasonable, I see now where they are making up the difference by overcharging for same products I purchased here. I felt taken advantage of when I found out how much cheaper it is to order from Allivet at the advice of my co-worker

Cheryl Z Verified Purchase
April 26, 2021

I love the low prices at Allivet. I shop here all the time.

Keith J Verified Purchase
April 26, 2021

Works well to keep the ticks off my dogs even during the summer.

Krystyne A Verified Purchase
April 26, 2021

Flea meds are expensive. I've tried to cheap ones and they don't work. K9 Advantix does and the prices here are wonderful!

Keith J Verified Purchase
April 26, 2021

Works well to keep the ticks off my dogs even during the summer.

Joyce D Verified Purchase
April 26, 2021

Good price , good product, good service from allivet very simple site for old lady!!

Paula P Verified Purchase
April 26, 2021

Great price

Diane J Verified Purchase
April 26, 2021

this is a great product if you have a mosquito problem in addition to those darn ticks.

Melody K Verified Purchase
April 26, 2021

Great price!

Daniel M Verified Purchase
April 26, 2021

Works great!

Mark E Verified Purchase
April 26, 2021

my friend recommended this product, said it works very well

Elva R Verified Purchase
April 20, 2021

Great product! Works awesome even when needing to bathe my dogs repeatedly during the month between applications.

Patricia J Verified Purchase
April 19, 2021

K9 Advantix II is a definite winner. It protects better and I had a German Shepherd allergic to Frontline, but not the Advantix

Christina w Verified Purchase
February 22, 2021

lowest prices

Carol s Verified Purchase
February 19, 2021

We live in the woods, We always have plenty of fleas and ticks. This product works great. I never find them in the house or attached to our dogs.

Carol s Verified Purchase
February 19, 2021

I have to be careful putting these kinds of products on our Yorkie. She's tiny. No issues with a reaction, since she is so small. Great product.

Michael J Verified Purchase
February 2, 2021

quick ordering process and competitively priced

Alf H Verified Purchase
December 11, 2020

We've used this product on our animals for years with very positive results.

Rolando M Verified Purchase
December 8, 2020

Quality of service and easy access to customers.

Rosanne A Verified Purchase
December 4, 2020

My pup is a flea magnet! Gotta keep him on a regular regimen of flea control.

Paul S Verified Purchase
November 21, 2020

I've been ordering K9 Advantix II from Allivet for several years. We've not had any problems with fleas or ticks. The product is easy to use and effective. I use Allivet for all my animal health needs. The service is top-notch and they have frequently gone the extra mile to ensure my satisfaction.

Nancy E Verified Purchase
September 11, 2020

Always used K9 Advantix, upping to Advantix II

Carol K Verified Purchase
July 21, 2020

I do like the complete protection it gives Titan and I like the topical treatments much better than the oral. We go RV camping all the time and have never had any issues with fleas, ticks or mosquitos....

Brenda D Verified Purchase
July 1, 2020

I love the prices at Allivet!

Brittany M Verified Purchase
May 22, 2020

Awesome stuff! Never causes issues and dogs are relieved!

Kathy B Verified Purchase
May 5, 2020

Been ordering from Allivet for all my pet needs

Carlene B Verified Purchase
May 5, 2020

Great price. Great customer service.

Barbara H Verified Purchase
April 13, 2020

They are the best, saved me $65/ month in seizure meds for my Golden

Tom W Verified Purchase
April 7, 2020

Great price- free delivery

Dawn K Verified Purchase
April 7, 2020

Advantix keeps tics and mosquitos from attacking my dogs. This is also safer than lesser-known brands as some dogs may have seizures with tic medicine-My dogs haven't had any with this brand.

Luz A Verified Purchase
April 7, 2020

This product is the best one for my dogs. It protects them from flees and ticks so well I don't have to worry anymore, They play and sleep some much better I don't have to worry when they play outdoors inside my home fence. I am very pleased with this product. I love my two dogs very much and am very much satisfied with this protection against fleas and ticks. Thank you so much and have a good day!

Maribel R Verified Purchase
April 7, 2020

Fantastic website

Wendy b Verified Purchase
March 3, 2020

Works great for my Maltese

Robinell h Verified Purchase
January 20, 2020

works well with my dog

Justin Y Verified Purchase
January 20, 2020

The best on the market!

Questions & Answers