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Proin ER

By Proin
(104 reviews)
Veterinary Diet Item
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Proin ER

By Proin
$22.82
One-time purchase
$13.69 AutoShip & Save up to 40%
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Product Overview

Proin ER (phenylpropanolamine hydrochloride) is for the control of canine urinary incontinence due to urethral sphincter hypotonus. It provides the same proven efficacy as PROIN chewable tablets but in extended-release tablets for once-a-day dosing.
*This item can't be shipped to AR, IA, LA, OR, WV.
Proin ER (phenylpropanolamine hydrochloride) is for the control of canine urinary incontinence due to urethral sphincter hypotonus. It provides the same proven efficacy as PROIN chewable tablets but in extended-release tablets for once-a-day dosing.
Dogs
Provides effective treatment for urinary incontinence due to urethral sphincter hypotonus in dogs.
Convenient – Given with food, a single dose per day simplifies treatment.
Innovative – Patented release technology provides controlled release that ensures steady absorption.
Easy to Administer – Chewable, liver-flavored tablets improve compliance.
Easy to Prescribe – Four dosing strengths based on body weight to provide simplicity.
FDA Approved.
PROIN ER works by increasing urethral sphincter muscle tone to help prevent urinary leakage. Proin contains the active ingredient phenylpropanolamine, an adrenergic agent that works by tightening the urethral sphincter muscle.
The most commonly reported side effects are vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink).
Phenylpropanolamine Hydrochloride
Contact your nearest emergency animal hospital.
Keep away from children and animals. PROIN ER may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure.
30 Tablet or 90 Tablet Bottle in the following strengths : 18 mg (for dogs 10-20 lbs), 38 mg (for dogs 21-40 lbs), 74 mg (for dogs 41-80 lbs), 145 mg (for dogs 81-125 lbs).
PRN Pharmacal, Inc.
Use as directed by your veterinarian.
Phenylpropanolamine Hydrochloride

About This Product

Customer Reviews

4.9
104 reviews
5 97
4 6
3 1
2 0
1 0
Customer review photo
Preston S Verified Purchase
October 9, 2026

Very convienent

Amy H Verified Purchase
August 20, 2026

First Day

We were skeptical, but Proin ER worked on the first day. Our dog was only 2, but she's been on it for 3 years now with no side effects.

Heather S Verified Purchase
August 19, 2026

No leaks!

My girl had a big problem with post spay leaking. She's been taking ProinER for the past 7 yrs and has had no leaking. We have the prescription on autoship with Allivet and have had no issues. Good service, good price!

Beth L Verified Purchase
July 29, 2026

Older dog issues

It has been amazing for my 13 year old dog. She used to have accidents while sleeping and get up confused as to why her bed is wet. Now she rests well and no longer has this issue.

Cheryl B Verified Purchase
July 1, 2026

Review

Proin has helped my doberman for the last few years extremely well. No more in incontinence and I can even skip a day between doses. Satisfied with this product.

Michele S Verified Purchase
March 25, 2025

Gamechanger!

My pittie mix was diagnosed with urinary incontinence at age 3. Proin ER is the best! No more leakage when she sleeps, and no more worrying about wet furniture or bedding. Thank goodness for this drug!

Denise T Verified Purchase
February 13, 2025

We had adopted Pepper at 16 months. She had urinary leakage a couple of months after we got her. She had a caesarean at 1 year old and that caused the problem. She takes DES hormone and Proin and that has solved the leaking problem.

Thomas M Verified Purchase
February 1, 2025

Works great on older dogs

My 9-year-old dog started leaking pee. The Vet put her on one pill a night at supper time & it fixed the problem.

Anonymous Verified Purchase
October 24, 2024

Since giving Piper Proin 74, she has stopped biting at her bottom and we sleep all night. Before we were up all night and she would leave round spots of urine wherever she was.

Kristy P Verified Purchase
September 18, 2024

My 95lb bulldog suddenly lost control of her bladder and was letting her full bladder release in her sleep at night and leaking during the day. This medicine stopped the full bladder loss and after 2 weeks leaking is minimal.

Judy S
July 11, 2024

I use proin for both my dogs. Been on this for over 6+ years. Really helped from day one to control urine leakage. Great product. Will continue to use it. Allivet has been great to deal with. Friendly staff. Product always delivered on time. Good price.

June m Verified Purchase
April 29, 2024

This medication completely keeps my dogs incontinence under control so that she can live a normal life.

RoseAlia S Verified Purchase
December 29, 2023

My young female dog started having issues with bladder control and she would leak while resting, playing, eating, etc. Took her to the vet, they prescribed her Proin ER and like magic, the leakage stopped. I highly recommend this if your dog has a bladder problem.

Matthew C Verified Purchase
November 15, 2023

Our dog has urinary incontinences and I swear by Proin ER. We have been giving this to her for almost 4 years now and haven't had any issues. No leaking and she is a happy dog.

Josh B Verified Purchase
September 29, 2023

Proin has kept my boxer from losing her bladder on our floors. She drinks more water with it but is able to hold her pee. Awesome product. I am lowering the dose to see if it still works

Jamie C Verified Purchase
August 26, 2023

I have been using for 5 years with my female dog who developed incontinence after her spay surgery. This product works wonders!!!

Cookie A Verified Purchase
July 1, 2023

Our 6 year old dog suddenly started leaking urine. What a mess for us and she actually looked confused and embarrassed. Our Vet recommended Proin ER and told us of the success rate his patients have had on it. To us it was a miracle, she stopped leaking almost immediately and everyone was no longer stressed out!

Linda S
May 26, 2023

I have a 155 lb Great Dane who developed spay incontinence after she got fixed. Every time she laid down there was a wet spot. It got really bad as the other 2 Danes wouldn’t lay on the beds because of her leaking. First dosage of Proin and she’s leak free! I’m so grateful for this medicine.

Haydee F Verified Purchase
May 25, 2023

It helped my older dog control her bladder

Nancy R Verified Purchase
April 27, 2023

This med has helped my old girl a lot. Side effect of anxiety happened twice but that has improved now we’re into 2nd month. Sure beats struggling to put diaper on or washing bedding.

Liz
January 27, 2023

Seems to work well for our dog, who's older with a number of issues. She rarely has any accidents or leaking, and tolerates it well. I appreciate being able to get it online. I'd love to support our vet's online pharmacy or just get it from them, but the prices are much higher in office or via their online pharmacy. With all the meds our dog is on, it costs a fortune every time we go to the vet, so every med we can get that's a bit lower in price helps.

Margaret E Verified Purchase
January 17, 2023

When my Great Dane Eivie was first prescribed this, the vet put her on 2 pill a day which made her horribly ill. The vet said give her 1 a day and see how she does. Well since 12/12/22, Eivie has had (0) accidents!!! So going from one a night to none a night is phenomenal!! I love this drug as the dose is right for her now and she tolerates it very well!!! Proin ER truly does work!!

Kayla H
October 17, 2022

Works well for my dog. Since putting my dog on this, it has helped with her bladder. When she relaxes, she would urinate. Now, no accidents! :-). Just only had issues with the Vet approving the prescription. Had to call multiple times to the vet and Allivet to confirm it.

Laurel
October 8, 2022

This medicine worked very well at the start (about one year ago). It is not working well now, and I suspect my dog needs a change in strength perhaps. That is not the medicine’s fault, and it really worked well when we started, therefore a 5* rating.

Carol C
October 4, 2022

Our 11 year old German Shepherd Dog is blinds and just suddenly developed incontinence. Our vet, a family friends, prescribed Proein and it immediately took care of the issue with no other side effects. Allivet gives the best price and great service and we are very pleased to do business with them.

Lisa B Verified Purchase
August 27, 2022

I haven't gotten the medication yet; however I am saving with my coupon about 15.00 a bottle then my vet is charging. I would have used the auto refill but the % saved is reduced from 10% to 5%. Also, shipping is a little high especially if you need the medication quickly. So, I am giving 4 stars

Sigrid M Verified Purchase
March 28, 2022

doesn't help much

Jena B Verified Purchase
March 15, 2022

Can,t say enough about this product. If we miss a day she has an accident in her sleep.

Kathy M Verified Purchase
February 28, 2022

Our dog no longer leaks when sleeping since she started taking these.

Franck L Verified Purchase
February 14, 2022

Good Price Good service

Tonya S Verified Purchase
January 25, 2022

Works great on her urine problem

Janet B Verified Purchase
January 25, 2022

Cheaper than other Pharmacys. Good Service. Hoping Auto Subscription works as it should.

Susan F Verified Purchase
January 25, 2022

product works great, but takes too long to ship almost have to order month in advance

Darren S Verified Purchase
January 25, 2022

The pills.work great my dog has very few accidents since taking.

Andrew T Verified Purchase
January 25, 2022

Has worked very well in stopping uncontrollable urination in my dog. She hasn't had any issues since starting the medication.

Marsha B Verified Purchase
January 25, 2022

my beautiful young Shepherd rescue was peeing small and frequent. Even on our bed! This is awesome.

Betty S Verified Purchase
January 25, 2022

This product is more than a blessing to me as a pet owner. As my female Doberman aged she began having problems with urinary incontinence. This meant always having to keep a pad and britches on her and a mop . This medication has changed all that. There is no longer that dribbling when she's relaxed. That has totally disappeared on this medication. No more pad, britches, or mops. Thank you!

David C Verified Purchase
November 19, 2021

This works great to curb our puggle's incontinence. 3 months for slightly more than the price of what my local vet charges for a single month.

Jeanne L Verified Purchase
November 16, 2021

Since she's been taking this, not one accident. She won't chew it despite being one. I have to hide it in peanut butter.

Natalie V Verified Purchase
November 15, 2021

Priced better than other options.

Therese M Verified Purchase
November 15, 2021

Works perfectly

Sabrina R Verified Purchase
November 11, 2021

It assist my dog with keeping her bladder under control. Works great.

Vince P Verified Purchase
November 3, 2021

Best price online!

Nancy S Verified Purchase
November 3, 2021

great product for our dog hope

Nadine T Verified Purchase
October 27, 2021

Works for urinary leakage perfectly!

Jeff C Verified Purchase
October 5, 2021

Best deal

Robert B Verified Purchase
September 28, 2021

No more accidents, yea! Allivet is the best. Customer service that can’t be beat.

Sara H Verified Purchase
September 23, 2021

Works well for my mastiff, she's 140lbs and only take 74mg, the larger tablets made her throw up. So a lower dose has been great

VICTORYA R Verified Purchase
September 23, 2021

As my dog has aged she has lost some bladder control. Thanks to Proin, she is no longer "leaking" and can live her normal life! No more stinky dog bed, and she can sleep on the couch again.

Terrie S Verified Purchase
September 7, 2021

My elder dog, Gracie had some urinary leakage causing issues in the house however Proin has been successful in stopping this leakage and our girl is happily allowed on the rugs again . My orders are delivered on time without hassle. Thanks Allivet

Traci M Verified Purchase
September 2, 2021

price is good. helped my dog not have leaking

June m Verified Purchase
September 2, 2021

My miniature poodle was diagnosed with incontinence at the young age of 3. She has been taking Proin and now Proin ER for 4 years now and has never had an accident since taking this miracle pill.

Susan P Verified Purchase
August 23, 2021

The price is lower than my vet price

Wesley R Verified Purchase
August 23, 2021

Works wonders for incontinence

Al B Verified Purchase
August 12, 2021

Very happy to have found you guys! Same product that the Vet has but saves me a bunch. Thanks.

Roy W Verified Purchase
July 20, 2021

I bought this because my vet prescribed it.

Lynn V Verified Purchase
July 8, 2021

15-year-old dog has urinary incontinence. This pill has worked miracles for her.

William W Verified Purchase
July 8, 2021

not available through vet due to shortage. simple to order through Allivet

Elizabeth W Verified Purchase
June 29, 2021

Because my vet is always out of stock and so is the other 2 online vet pharmacys

Renee H Verified Purchase
June 25, 2021

Excellent pricing

Nikole B Verified Purchase
June 14, 2021

Fast shipping! Great quality and price !

Kary E Verified Purchase
June 8, 2021

It seems to help, and Allivet has the best pricing.

Jeff T Verified Purchase
June 7, 2021

Our little girl dog is now 13 and 1/2 and has a urinary incontinence problem, especially at night. After years of sleeping on the bed with us, she cried all night when we put her in a kennel for the evening. No sleep for us! We heard of Proin, talked to our vet and decided to give it a try. As long as we put het outside prior to us going to bed, she has been urine accident free through the night for almost three weeks now. This is a game changer for us. No noticeable side affects (we use the extended release formulation). We will be getting the pill monthly on automatic re-order basis in the future..

Diane P Verified Purchase
May 27, 2021

Great prices, fast shipping! Thank you!!!

Whitney R Verified Purchase
May 26, 2021

Prior to joining my family, my dog, was the victim of overbreeding to the point of having a prolapsed uterus and inguinal hernias, which has caused severe urinary incontinence. This product has changed her life so much! She took regular Proin in the past, but this seems to agree with her stomach more and she has more of an appetite. She still has occasional leakage during times of stress or worry, but it has greatly diminished!

Lance T Verified Purchase
May 25, 2021

BETTER THAN REGULAR PROIN

Angela B Verified Purchase
May 16, 2021

It works!

Carol T Verified Purchase
May 11, 2021

Buying from Allivet is a great savings from someone on a fixed income

Debra E Verified Purchase
May 3, 2021

It is $20 bucks cheaper than my vet, so that is $240 in savings a year

Mary B Verified Purchase
May 3, 2021

If I didn't the entire house and family would smell like peepee.

Crystal R Verified Purchase
May 3, 2021

Excellent price and shipping

Kristy S Verified Purchase
May 3, 2021

I think I’ll be completely satisfied with my experience the price was super affordable!!

Yuriy S Verified Purchase
May 3, 2021

my dog needs them

Breezy a Verified Purchase
May 3, 2021

Best price around without any special discounts

Al B Verified Purchase
May 3, 2021

Excellent folks to deal with. Affordable and reliable.

Carolyn S Verified Purchase
April 26, 2021

My dog needed these ASAP. Allivet handled it quickly and I am very happy

Teresa B Verified Purchase
April 26, 2021

This is was the best price and quickest shipping I could find for this med. my Ver was slow to respond with script. Allivet followed up with them everyday as well as sent me an email update everyday until they responded. I found this extremely helpful.

Sarah M Verified Purchase
April 26, 2021

Good so far. Have not had any issues or side affects. Will continue using it.

Mary R Verified Purchase
April 26, 2021

Works well. Allivet has good price. Easy to order.

Jeanne H Verified Purchase
April 26, 2021

Great medicine for my old dog with urinary incontinence

Cornelius C Verified Purchase
April 26, 2021

Price is great

Wendell S Verified Purchase
April 26, 2021

Great Product

Susan F Verified Purchase
April 26, 2021

Very fast shipping. Great prices. Customer service is great.

Dana S Verified Purchase
April 26, 2021

Best price and they work great!

Deborah A Verified Purchase
April 19, 2021

Helped stocked incontinence effectively

Susan P Verified Purchase
April 19, 2021

My vet charges twice as much for the exact same item.

Rena B Verified Purchase
March 19, 2021

The price is half what my vet charges.

Pamela M Verified Purchase
February 19, 2021

We started our pet on this a month ago for incontinence and have had no accidents works great!

Sheri N Verified Purchase
February 6, 2021

Our young dog has bladder issues and this product helps the continuous leaking to almost stop.

Deborah C Verified Purchase
February 3, 2021

Good price and always delivered on time

Kathleen H Verified Purchase
January 12, 2021

I have to go to the Vet either once a month or every other month to pick up her prescription and I thought this would be so much easier and less expensive. Thanks :)

Ashlee R Verified Purchase
December 1, 2020

My vet recommended this to help my dog with her incontinence, and it has helped tremendously.

Carol T Verified Purchase
November 24, 2020

So much cheaper than the vet and same medication. I am on a fixed income.

Cindy N Verified Purchase
October 29, 2020

Affordable price, great service!

Debbie M Verified Purchase
October 21, 2020

Keeps her from dripping pee all over!

Lori K Verified Purchase
September 18, 2020

Very quick service and I like the auto ship. I never have to worry about Hollie running out of her pills.

John H Verified Purchase
September 1, 2020

Smooth Website - everything worked

Thomas S Verified Purchase
August 21, 2020

Allivet has become our choice for all our pet medication needs. Their prices and customer service are incredible!

Shawnda L Verified Purchase
July 29, 2020

This is so much cheaper on Allivet than at the vet Hospital. Thank you!

DOUGLAS K Verified Purchase
July 21, 2020

I used to have to give my dog 4 one-half tablets a day. It is SO nice to only have to give her one tab at mealtime. And it works just as well as the old way.

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