How often do I give Vetsulin to my dog? Once a day? Or twice a day?

How often Vetsulin is given depends on your dog’s individual treatment plan and response to insulin. Please administer Vetsulin exactly as prescribed by your veterinarian and consult them before making any changes to the dosing schedule.

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Vetsulin

By Vetsulin

(504 reviews)

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Vetsulin Insulin for Dogs and Cats 10 ml Vial

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Vetsulin

By Vetsulin

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Size: 10 ml

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Product Overview

Vetsulin® (porcine insulin zinc suspension) is approved by the FDA to reduce hyperglycemia and associated clinical signs in pets with diabetes mellitus.

Vetsulin is an ideal insulin choice for your canine and feline patients with diabetes. It is an FDA approved prescription insulin manufactured by Merck Animal Health that is used to reduce hyperglycemia and hyperglycemia-associated clinical signs.

For use in cats and dogs.

Vetsulin® is the only insulin approved by the FDA for use in diabetic pets in the United States.

Porcine insulin has a similar amino acid structure to canine insulin. It is considered an intermediate acting insulin.
Vetsulin® has two activity peaks after administration in dogs - one around 4 hours and another around 11. Activity duration varies, but is typically 14 to 24 hours.
In cats, the activity peak occurs between 1.5 and 8 hours, and activity duration varies at 8 to 12 hours.
Peak activity, activity duration, and required dose to adequately control diabetic symptoms will all vary between patients.

While rare, allergic reactions may occur. Immediately seek emergency veterinarian attention if your pet experiences such a reaction (including swelling of the face, tongue, or lips, hives, or difficulty breathing).

Other severe reactions may occur with or without warning. The most frequently-experienced insulin-related reaction is hypoglycemia (low blood sugar), which may cause the following symptoms:

Coma
Seizures
Staggering gait (incoordination)
Lethargy

Immediately reach out to your veterinarian if your pet exhibits signs of a side effect or medical problem. Speak with your veterinarian if your pet seems unusually bothered by a side effect.

Vetsulin® is a sterile aqueous zinc suspension of purified porcine insulin.

Immediately contact your veterinarian or closest in case of overdose
rogestogens, certain endocrinopathies, and glucocorticoids can have an antagonistic effect on insulin activity
Overdose can result in profound hypoglycemia and death

Stabilization with short-acting insulin and supportive therapy should be offered to animals who present with:

Anorexia
Vomiting
Lethargy
Ketoacidosis

All patients undergoing insulin treatment should be monitored carefully for hyperglycemia and hypoglycemia. This is fundamental in preventing complications and in attaining and maintaining adequate glycemic control.

Incorrect dosing will occur if any syringe is used other than Intervet U-40 Insulin Syringes.

Vetsulin® should only be administered subcutaneously to cats and dogs.

Vetsulin® is supplied as a sterile injectable suspension in multidose vials containing either 2.5 mL or 10 mL of 40 IU/mL porcine insulin zinc suspension. Vials are supplied in cartons of one 10 mL vial and cartons of ten 2.5 mL vials.

Merck Animal Health

Take time to carefully review the information sheet included with every prescription.

Vetsulin should be mixed by gentle rolling of the vial prior to withdrawing the dose from the vial. Using a U-40 insulin syringe, the injection should be administered subcutaneously, 2 to 5 cm (3/4 to 2 in) from the dorsal midline, varying from behind the scapulae to the mid-lumbar region and alternating sides.

Vetsulin for Dogs

The initial recommended dose of Vetsulin® for dogs is 0.5 IU insulin/kg body weight. This dose should be given once daily concurrently with, or right after a meal. Your veterinarian should re-evaluate your dog at appropriate intervals and adjust the dose based on clinical signs, urinalysis results, and glucose curve values until adequate glycemic control has been attained.

In the US clinical study, glycemic control was considered adequate if an acceptable blood glucose curve was achieved (reduction in hyperglycemia and a nadir of 60 - 160 mg/dL), clinical signs of hyperglycemia (polyuria, polydipsia, and ketonuria) were improved, and hypoglycemia (blood glucose < 50 mg/dL) was avoided. Twice daily therapy should be initiated if the duration of insulin action is determined to be inadequate.

If twice daily treatment is initiated, the two doses should be 25% less than the once daily dose required to attain an acceptable nadir. For example, if a dog receiving 20 units of Vetsulin® once daily has an acceptable nadir but inadequate duration of activity, the Vetsulin® dose should be changed to 15 units twice daily.

Further adjustments in dosage may be necessary with changes in the dog's diet, body weight, or concomitant medication, or if the dog develops concurrent infection, inflammation, neoplasia, or an additional endocrine or other medical disorder.

Vetsulin for Cats

The initial recommended dose of Vetsulin for cats is 1 to 2 IU per injection. The injections should be given twice daily at approximately 12 hour intervals. For cats fed twice daily, the injections should be given concurrently with, or right after each meal. For cats fed ad libitum, no change in feeding schedule is needed.

Your veterinarian should re-evaluate your cat at appropriate intervals and adjust the dose based on clinical signs, urinalysis results, and blood glucose curve values until adequate glycemic control has been attained.

Further adjustments in dosage may be necessary with changes in the cat's diet, body weight, or concomitant medication, or if the cat develops concurrent infection, inflammation, neoplasia, or an additional endocrine or other medical disorder.

Vetsulin is a sterile aqueous zinc suspension of purified porcine insulin.

Each mL contains:

- 40 IU of purified porcine insulin (30% amorphous and 70% crystalline)

- Zinc (as chloride): 0.08 mg

- Sodium acetate trihydrate: 1.36 mg

- Sodium chloride:7.0 mg

- Methylparaben (preservative): 1.0 mg

pH is adjusted with hydrochloric acid and/or sodium hydroxide.

About This Product

Vetsulin Description

Vetsulin® (porcine insulin zinc suspension) is approved by the FDA to reduce hyperglycemia and associated clinical signs in pets with diabetes mellitus.

What is Vetsulin?

Which animals/pets is Vetsulin for?

For use in cats and dogs.

Vetsulin uses

Vetsulin® is the only insulin approved by the FDA for use in diabetic pets in the United States.

What does Vetsulin do?

Porcine insulin has a similar amino acid structure to canine insulin. It is considered an intermediate acting insulin.
Vetsulin® has two activity peaks after administration in dogs - one around 4 hours and another around 11. Activity duration varies, but is typically 14 to 24 hours.
In cats, the activity peak occurs between 1.5 and 8 hours, and activity duration varies at 8 to 12 hours.
Peak activity, activity duration, and required dose to adequately control diabetic symptoms will all vary between patients.

Vetsulin side effects

Coma
Seizures
Staggering gait (incoordination)
Lethargy

Immediately reach out to your veterinarian if your pet exhibits signs of a side effect or medical problem. Speak with your veterinarian if your pet seems unusually bothered by a side effect.

Vetsulin ingredients

Vetsulin® is a sterile aqueous zinc suspension of purified porcine insulin.

Vetsulin overdose: What to do?

Immediately contact your veterinarian or closest in case of overdose
rogestogens, certain endocrinopathies, and glucocorticoids can have an antagonistic effect on insulin activity
Overdose can result in profound hypoglycemia and death

What to know before using Vetsulin

Stabilization with short-acting insulin and supportive therapy should be offered to animals who present with:

Anorexia
Vomiting
Lethargy
Ketoacidosis

How is Vetsulin sold?

Manufacturer

Merck Animal Health

Tips for using Vetsulin

Take time to carefully review the information sheet included with every prescription.

Overview

Vetsulin for Dogs

Vetsulin for Cats

Main Ingredients

Vetsulin is a sterile aqueous zinc suspension of purified porcine insulin.

Each mL contains:

- 40 IU of purified porcine insulin (30% amorphous and 70% crystalline)

- Zinc (as chloride): 0.08 mg

- Sodium acetate trihydrate: 1.36 mg

- Sodium chloride:7.0 mg

- Methylparaben (preservative): 1.0 mg

pH is adjusted with hydrochloric acid and/or sodium hydroxide.

Customer Reviews

4.9

504 reviews

5 479

4 25

3 0

2 0

1 0

Susan S Verified Purchase

July 20, 2026

Well packaged cold delivery.

Because insulin needs to be refrigerated, I was a bit worried about my shipment from Indiana to California. It arrived quickly and in great shape. Multiple layers of insulation, freezer packs, etc.

Danny g

November 28, 2022

Excellent service and speedy shipping!

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Simparica Trio ^Rx

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Credelio Quattro CA1

NexGard Combo ^Rx

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ToMORROW ^Rx

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