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Proin

By Proin
(1,184 reviews)
Veterinary Diet Item
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Proin

By Proin
$35.41
One-time purchase
$21.25 AutoShip & Save up to 40%
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Product Overview

For dogs experiencing incontinence issues, Proin can provide relief. This FDA-approved medication comes in a chewable tablet containing phenylpropanolamine to aid in the treatment and management of urinary incontinence in dogs. It works as an adrenergic agent to help dogs with leakage of urine by tightening the bladder sphincter muscle.
*This item can't be shipped to AR, IA, LA, OR, WV.
Proin is a chewable tablet used for the management and treatment of urinary incontinence in dogs. Proin is manufactured by PRB Pharmacal, Inc and contains phenylpropanolamine. It is available in all states except Arkansas, Georgia, Hawaii, Iowa, Louisiana, Oregon or West Virginia, where it is classified as a controlled substance.
Proin is intended for use in dogs with leakage of urine or urinary incontinence.
  • Chewable Proin tablets are intended to treat dogs with urinary incontinence.
  • Proin works by maintaining bloodstream levels of phenylpropanolamine.
  • Can aid in the reduction of symptoms associated with increased phenylpropanolamine levels such as:
    • Heart rate changes
    • Increase in blood pressure
    • Hyperexcitability
    • Decrease in appetite
  • Proin works to tighten the urethral sphincter muscle responsible for the prevention of urine leaking. Its active ingredient is phenylpropanolamine which works as an adrenergic agent.
    Phenylpropanolamine is known to cause a response known as "fight or flight." This may lead to side effects including:
    • High blood pressure
    • Increase in heart rate
    • Restlessness
    • There may also be a reduction or loss of appetite which may have long term issues.
    Phenylpropanolamine Hydrochloride
    In case of Proin overdose contact your veterinarian or veterinary emergency room. Symptoms of overdose may include increased thirst, urination and hunger, hyperactivity, personality change, and reduced heat tolerance.
    Dogs exhibiting hypersensitivity to Anipryl should not take the drug. Keep out of reach of children and pets.
    Proin Chewable tablets are available in 25mg, 50mg, and 75mg strengths in 60 or 180 count bottles.
    PRN Pharmacal, Inc.
    The main cause of urinary incontinence in dogs is infection of the bladder which leads to an increased urge to urinate. Bladder infections in dogs means their bladders are only emptied partially during urination. Consequently, urine is smelly because it is only partially emptied.

    Blood may appear in the urine from cancer, calculi or tumors which can cause infection.
    Use as directed by your veterinarian. The usual dose of Proin for dogs is 0.4-0.8mg/pound every 12 hours.
    Active Ingredient : Phenylpropanolamine Hydrochloride

    About This Product

    Customer Reviews

    4.9
    1,184 reviews
    5 1125
    4 59
    3 0
    2 0
    1 0
    Customer review photo
    Customer review photo
    Fannie L Verified Purchase
    September 29, 2026

    Proin tablets

    Alivet supplies my Furbaby the medicine she requires. Proin helps my furbaby with her urinary tract. Alivet adjusts the scheduled reorder easily and let's me know in advance of the next shipment.

    Heidi W Verified Purchase
    September 17, 2026

    This is a furniture saver!

    This has been a furniture saver at my house! My standard poodle has always had a leaking problem. It’s so much better now!

    Chester T Verified Purchase
    September 1, 2026

    Bed wetters

    My vet prescribed proin for my 3-year-old Rhodesian Ridgeback who had developed bladder problems. Bless her heart she was really good at going out but she started waking up with a wet bed at night she's been on these now for 11 years with no side effects no wet bed just in the last year I've had to increase the dosage to two half tablets a day instead of one half but excellent product if you have a dog with a leaky bladder that's what it's for.

    Tina W Verified Purchase
    August 23, 2026

    Amazing product!

    Unfortunately for me, I have been purchasing Proin for over 13 years now. (ALL of my rescued female pups were on it for years!) It works great and is one of the best products on the market! Be sure to administer twice a day and you are good to go. If your pup needs surgery, be sure to ask your vet to make sure that they can have it that morning to avoid an accident that night! Highly recommend from over a decade of experience.

    Paula G Verified Purchase
    August 20, 2026

    It works

    Our fur baby is 15 1/2 and is in continent. The 75mg tab given twice a day (broken in half for each dose) works very well. The cost from our vet was absurd so I’m glad we found Allivet. The first bottle was damaged but they replaced it without any argument or problems. That is how I rate a vendor. They did well. Thanks.

    Terry P Verified Purchase
    August 17, 2026

    It helps our dog from what i call a leaky bladder often common in Drathars.

    Scott J Verified Purchase
    August 14, 2026

    Proin Review

    Works great on out standard poodle with no issues.

    Barry B Verified Purchase
    August 10, 2026

    It’s good stuff

    Sally C Verified Purchase
    June 3, 2026

    Allivet Best Customer Service!

    Proin is very effective for my senior female dogs. Allivet has the best price too! More importantly, Allivet has the kindest, most compassionate customer service employees when I inadvertently ordered for my hospice dog. Bless them!

    Cheri T Verified Purchase
    November 18, 2025

    Proin 50 mg tablets

    Our 12 year old border collie takes one every twelve hours. This prevents her from "leaking" in the house. It was GREAT to get a 90 day supply from Allivet!

    Ingrid H Verified Purchase
    October 31, 2025

    It really works; problem solved

    I have an older dog and her being on the pro and 50 mg twice a day has really helped no dribbles no accidents nothing life is really good. It’s worth getting.

    Patricia L Verified Purchase
    August 23, 2025

    Incontinence in dogs

    My lab mix 10 year-old dog has been incontinent almost her whole life. Proin has helped but she will have to take it for the rest of her life. There is no cure that I know of.

    Jessica D Verified Purchase
    July 9, 2025

    Feels like a miracle drug

    My elderly female dog, Singer, was leaking and she didn’t even know it was happening. She would get up and there would be a giant wet spot. It felt like we were washing bedding every other day and she was embarrassed and constantly licking herself. After ruling out other possible medical conditions the vet recommended this and all of the issues stopped almost immediately. This was a few years ago and she will be turning 15 in 2 months and is still going strong and in control of her bladder!

    Robert Y Verified Purchase
    May 20, 2025

    Very welcomed reminder

    I have a 11-year-old female dog who's been on this medication almost her entire life and although the prices have always increased more than I would think is reasonable. This company has found a way to reduce that pain, knowing that she will continue to use the medication the rest of her life. Without the reminders I would forget where I bought it from and they make it simple to order my content to my veterinarian.

    Tiffany z Verified Purchase
    April 4, 2025

    Great product for my aging dog at an amazing savings from buying at my vet's office

    As my dog has aged, she was having leaking pea issues and this medicine stops it! When she only needed one pill a day, no problem buying from my vet but now that she needs 4 pills a day it was getting more expensive and the savings was significant to buy from Allivet!

    Cynthia L Verified Purchase
    April 3, 2025

    Effective 90% of the time.

    Proin seems to be effective 90% of the time but my dog still has accidents occasionally. It appears that he does not get the feeling you have when you bladder needs to be emptied. He is trained to pee on command so that does help.

    Joyce S Verified Purchase
    December 2, 2024

    Success

    After my 105 pound German Shepherd lab was diagnosed with incontinence she was put on Proin. Allivet has provided quality medication on a timely basis for Molly. For her to go without it is disastrous since she’s a house dog.

    Keena L Verified Purchase
    November 28, 2024

    has helped my girl for many years now with her leaking urine when she gets up from laying position. Allivet, always helpful and quick to receive once your prescription is received from vet.

    Deborah M Verified Purchase
    November 25, 2024

    Allivet is THE best !!!

    Allivet is my "go to" for all my dogs' medical needs! Allivet customer service is superb--they are VERY responsive when I had an issue of late mail delivery--no fault of their own, but they went beyond and overnight shipped my dogs meds that were keeping her alive. THANK YOU SO MUCH ALLIVET!!!!!

    Anonymous Verified Purchase
    November 10, 2024

    While we were on vacay my 12 y/o became incontinent. We got home, made the realization it wasn’t infection. Within two days of being the med we had no accidents at night.

    JAMIE M Verified Purchase
    September 9, 2024

    My girl has been on this for years. She is on it due to her spay causing some bladder leakage. She was spayed at about 6 months and she is now 7. She gets one every day and she has no leaks.

    Jennifer R
    June 10, 2024

    Night and day difference!! My dog is completely incontinent with out this medicine. She was out for a couple of days and I was quickly reminded of what life was like before Proin. Saves my dog’s dignity.

    Stacy W Verified Purchase
    March 11, 2023

    These seem to help our 15 year old so she doesn’t trickle urine anymore.

    Michelle g Verified Purchase
    February 17, 2023

    My yellow lab Maggie has incontinence and was having trouble holding her potty. She would just be sleeping and a puddle would form underneath her. Once she started using Proin tablets it all stopped. It was a miracle. Thank you

    Kari J
    January 30, 2023

    Both my labs have been on this med for several years. Has worked great helping with their incontinence with no side effects. They take them like treats!

    Lisa M
    January 20, 2023

    I have a 12 year old Springer Spaniel female who has been taking this for most of her life. It has worked great for her. This is a great price with a huge bottle that lasts me for three months. My girl has not had any side effects or bad experiences with this. She will continue to take it and I will be buying more.

    Mary
    January 3, 2023

    I have researched many different sites and I find Allivet the easiet to work with and the pricing is better. I have my dogs medicine on auto ship and I love that. Piper always gets her meds on time.

    Nancy M Verified Purchase
    January 2, 2023

    They work great for my dog

    Diane G Verified Purchase
    December 15, 2022

    I have ordered from Allivet for years. They have the best prices and they ship quickly.

    Michele C Verified Purchase
    November 21, 2022

    Easy to Order/Refill....Fast Shipping!

    MURDOCK, C
    November 9, 2022

    The people in customer service are very helpful. My dog has been on Proin for a couple years now but Allivet is now my go to pharmacy since they make it easy to order and have good prices.

    Toree W
    November 6, 2022

    I was desperate. Nothing was working. Finally at dog training class, I was venting how my dog Peed all over the place and somebody said, there’s medication for that. It’s a long story but the shelter where I got her was giving me the runaround for a year and NEVER mentioned that there might be a solution, they just kept telling me to bring her back and relinquish her. I was tempted. The thing is, they knew that she had an issue but they didn’t tell me. And, as a medical facility, they should have known there was an easy solution. So I called up my own vet and she prescribed Proin. It was an instant fix! I came so close to giving her up because it was awful living with urine on the bed, on the couch, on the dog beds, everywhere! Restricting her water didn’t help. Thank goodness for this medication. It really truly works.

    L H
    November 3, 2022

    I have used this product for 2 yrs now and it works great for my Border Collie. It doubled in price at my local pharmacy. Allivet was able to give me the same price I was paying and even contacted my vet for the Rx! Excellent, very satisfied!

    Jennifer R Verified Purchase
    November 3, 2022

    $89 for 75mg 180ct on autoship versus $135 at my vet!

    Carolyn K Verified Purchase
    November 1, 2022

    Works great. Lowest price is here !!

    Glen M Verified Purchase
    November 1, 2022

    Our dog needed the medication. The cost at Allivet was half of that at the vet. Great service and they help all they can. Good folks to deal with

    Donna M
    October 23, 2022

    Our Giant Schnauzer has always been a gracious lady. Now her advanced years have brought some undesirable symptoms. Prion 75 mg has allowed her to be symptom free with no embarrassing bladder leakage. Thank you PROIN!

    Susan F Verified Purchase
    October 14, 2022

    it works! Lucy feels better than she has in several years.

    Greg D
    October 6, 2022

    Product works great with my dog. More importantly, Allivet is wonderful to work with and Delivers the service so many do not.

    Danielle
    October 4, 2022

    Been using this product for 6 years on my dog and works great. Best prices on this site!

    Louis P Verified Purchase
    September 30, 2022

    Best price for this item from all the companies I use for my pet.

    Mary S Verified Purchase
    August 30, 2022

    Great product! And lowest prices too!

    Valerie F Verified Purchase
    August 26, 2022

    Have always had good luck with getting my product in a timely manner

    Mary L Verified Purchase
    August 26, 2022

    I have used Proin for more than 3 years for my dog....works like a charm! No accidents!

    Don C Verified Purchase
    August 22, 2022

    Very good pet supply company

    Pieter O Verified Purchase
    June 23, 2022

    Works great without using estrogen

    Lynn C Verified Purchase
    May 22, 2022

    The cost is half the price of my vet's charge

    Anthony W Verified Purchase
    May 12, 2022

    50% Price savings

    Jaye A Verified Purchase
    May 11, 2022

    The vet quoted me $168 for the same prescription (over dbl). I have been thankful for Allivet keeping health care needs for my furry family members reasonable and accessible. I do wish you would add a feature where I could upload my prescription though...

    Michael M Verified Purchase
    April 25, 2022

    Great product for my female Boxador...her incontinence is finally under control since our vet told us it is very common for spayed female labs to have incontinence issues as they get older. She would be lying in her doggy bed asleep and she would start urinating uncontrollably which caused her distress when she realized she urinated in the house and thought she would be in trouble. The day she started this medication she no longer has incontinence issues. My vet is that good at diagnosing problems quickly with the best treatment plan and this medication solved our dog’s medical problems.

    Lisa M
    April 2, 2022

    This product works great for my 11 year old Springer Spaniel. She’s been taking it most of her life. I only need to give her one tablet so it does last me long time. I left a previous review stating I never received my order. The next day customer service called me, on a Saturday, and they will be reshipping me my order. Thank you so much! I will be back for more. Great prices and great service.

    Dona G Verified Purchase
    April 1, 2022

    it works most of the time

    Dona G Verified Purchase
    April 1, 2022

    it works most of the time

    Lisa M Verified Purchase
    March 31, 2022

    Works great for my 11 year old Springer Spaniel. She’s been taking this most of her life. No problems or complications.

    Diane b Verified Purchase
    March 31, 2022

    Good service and great prices

    DJ M Verified Purchase
    March 31, 2022

    Fast Delivery and best prices. They also contact my vet for me for refills when needed!!!

    Eric M Verified Purchase
    March 31, 2022

    Always the lowest prices!

    Caroline P Verified Purchase
    March 31, 2022

    It works for our Mollie

    Sandra T Verified Purchase
    March 31, 2022

    Best price for this medication!

    Cindy C Verified Purchase
    March 31, 2022

    Always receive my pets mediations right on time and in perfect condition! Very happy with Allivet!

    Sandra C Verified Purchase
    March 15, 2022

    Best price and rapid delivery...no hassle in every way!

    Moira H Verified Purchase
    March 10, 2022

    Prion has been a God send for our Molly. She is 14 yrs old and has had leakage issues especially at night until we started using Proin. She never has them now so I will never be without it. Must add Allivet takes care of all the work, getting prescription from your vet and getting the product to you asap! Very satisfied 👍🏼

    Leo B Verified Purchase
    March 9, 2022

    This medication has worked great for Roo's urinary incontinence!

    Virginia M Verified Purchase
    March 8, 2022

    It worked with the very first pill for my 16 year old dog's incontinence

    Donna G Verified Purchase
    February 22, 2022

    Shopping around on other sites and found Allivet they had the best prices and they have great service . Highly recommend them.

    Ruth A Verified Purchase
    February 19, 2022

    Great for my pup! Now she doesn't dribble on the floor.

    James M Verified Purchase
    February 14, 2022

    For my best friend in the whole world

    Nancy B Verified Purchase
    February 8, 2022

    Much cheaper than the Vet charges!

    Mike B Verified Purchase
    February 4, 2022

    Best price I could find

    Lillian D Verified Purchase
    January 31, 2022

    Proin is great so we do not have to worry about our pet having accidents.

    Jeffrey D Verified Purchase
    January 26, 2022

    Excellent price and availability with realistic auto-refill options

    Frederick H Verified Purchase
    January 25, 2022

    Cheaper than the vets price

    Crystal M Verified Purchase
    January 25, 2022

    Allivet has great prices and their autoship is always on time and very convenient. Would definitely recommend you check them out

    Lynn w Verified Purchase
    January 25, 2022

    Great price! No other clinic on or line business was able to meet or beat your price.

    Ron Z Verified Purchase
    January 25, 2022

    Works great for my German Shephard reduced peeing accident by 95%

    Rita S Verified Purchase
    January 25, 2022

    I bought Proin 50mg 180 ct here because I paid $92 @ my Vet’s office 10/21/21! That’s a huge difference!

    Margie S Verified Purchase
    January 25, 2022

    It has helped Zara with incontinence

    Patrick k Verified Purchase
    January 25, 2022

    Great service and easy to use the website

    Donna r Verified Purchase
    January 25, 2022

    Excellent service n 👏

    Vernon T Verified Purchase
    January 25, 2022

    this worked on our little girls accident problem and no find wet spots around the house.

    Gabrielle V Verified Purchase
    January 25, 2022

    Wonderful price and ease of ordering

    Eleonore I Verified Purchase
    January 25, 2022

    During the Pandemic, I couldn't locate my dog's prescription anywhere. Someone referred me to Allivet and low and behold they carried it. I have been depending on them ever since that time. I can depend on them supplying my dog's meds. I am very grateful.

    ML h Verified Purchase
    January 25, 2022

    QUICK DELIVERY!!! THEY CONTACT YOUR VET!!! EASY-PEASY! (Smile)

    Joe F Verified Purchase
    January 25, 2022

    Great!! Helps our older dog!!

    Dawn c Verified Purchase
    January 25, 2022

    Stopped my dog from leaking urine. It's wonderful!

    Alyssa G Verified Purchase
    January 25, 2022

    Older female dog has urinating issues can’t hold bladder. This stuff really works if given daily no accidents!

    Jennie L Verified Purchase
    January 17, 2022

    Shipping is faster than others I have tried. Prices are amazing, so much better than others.

    Jenine H Verified Purchase
    December 14, 2021

    The prices from Allivet are much more reasonable, than purchasing from my Vet. Thank you!!!

    Chester T Verified Purchase
    December 8, 2021

    ⅓ the local price even if it does cost me my vet. Obviously why, he has said he's apposed to all online drug shopping.

    Katherine G Verified Purchase
    December 8, 2021

    Allivet offers the best prices, speedy/reliable shipping and I love Autoship!

    Dick T Verified Purchase
    December 7, 2021

    Works great for our Great Dane.

    Larissa a Verified Purchase
    November 30, 2021

    My 110 lb King Shepherd developed incontinence last year, and the vet prescribed Proin at 100mg/2x day. A vet tech friend of mine suggested actually starting at half the dose, and she was right. I am giving 75mg just once per day and it's working great. At this level, I can increase the dosage as she gets older. This stuff WORKS!

    Wendy L Verified Purchase
    November 18, 2021

    Excellent price and quick order processing

    Toree W Verified Purchase
    November 16, 2021

    It’s a miracle. I struggled for a year with a dog who would pee at random times. The rescue center assured me it was normal puppy behavior. So I thought I was just crazy. Finally in dog class, someone mentioned that there was medication for that. So I saw my vet, she prescribed Proin and after the first dose – yes the first dose! – no more problem.

    Sarah K Verified Purchase
    November 15, 2021

    What a difference, it really helps!

    Jennifer F Verified Purchase
    November 15, 2021

    great prices, way cheaper than vet office, and it is shipped to house.

    Amy F Verified Purchase
    November 11, 2021

    Cheaper than buying from vet office.

    Justin P Verified Purchase
    November 11, 2021

    This product was recommended by our vet for balancing our female dog's hormones to help prevent bladder "leakage". It progressively worked and within about a month or two we noticed there were no more drainage issues.

    Roger R Verified Purchase
    November 8, 2021

    when other places dont have it Allivet did. thanks

    Sally C Verified Purchase
    November 8, 2021

    Best price around!!

    Questions & Answers